Big Pharma spends $6.5 billion on TV ads. The “chemical imbalance” theory was never proven. Joey and George break down how the system works — and what you can do about it.
On Episode 1 of the CRAZY podcast, Joey Nittolo and George Roumain sit in traffic on the 405 and dismantle the pharmaceutical industry's business model in under ten minutes. Not with conspiracy theories. With math.
“You put it in a box, you take a pill, and now your lifetime value — that's just one piece,” Joey says. “Now you're on a mental med. Now you have some heart condition because you're eating poorly, and now you have a heart med. And maybe you have some ADD too. And let's just give you some of that. Rather than teaching people how to give people tools to take care of themselves.”
George's response: “So what do we do? Sit here and bitch all day — or we can act on it? That's what we're doing.”
“It's all about putting people in the box, in the system, in a job you don't like, in traffic for three hours in LA so you get depressed and now you're taking a pill. I could keep going — big food, everything. Everything is to make you sick. So Big Pharma just keeps winning all day, every day.”
Joey's blunt assessment on CRAZY matches what a landmark 2022 umbrella review in Molecular Psychiatry confirmed: there is no consistent evidence that depression is caused by low serotonin or a “chemical imbalance.” The theory that launched a $30+ billion SSRI industry — and that millions of patients have been told is the reason for their medication — was never proven.
This doesn't mean SSRIs don't help some people. They do. But the mechanism may not be what the pharmaceutical industry claims. And if the foundational theory is wrong, the question becomes: what else might work — and why isn't the system investing in finding out?
Soul Syndicate exists because the alternatives Joey and George describe on CRAZY are real, evidence-based, and systematically suppressed by an industry that profits from your not knowing about them. Here are our master guides:
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